Human Sera
Cayman Chemical PrucaloprIde 50mg
A potent and selective 5-HT4 agonist (Ki = 2.5 and 8 nM for 5-HT4A and 5-HT4B, respectively); greater than 250-fold selective for 5-HT4 over a panel of 53 overexpressed receptors, including 5-HT subtypes, but does bind to human D4 and σ1 receptors and mouse 5-HT3 receptors (Kis = 2.3, 3.7, and 3.8 μM respectively); induces 5-HT4-dependent contractions in guinea pig colon (EC50 = 33 nM) and facilitates non-cholinergic contractions induced by electrical stimulation; increases colonic motility by inhibiting distal colon contractions in dogs (ED50 = 0.04 mg/kg, p.o.); increases acetylcholine and histamine levels in the rat prefrontal cortex and the power of hippocampal theta oscillations (5-10 mg/kg, s.c.)
Cayman Chemical 4 DImethylamIno1methylpyr 50mg
A pyridinium salt with anticholinesterase and antiproliferative activities; inhibits cholinesterase activity in rat brain homogenates (Kd = 33 μM); inhibits and yeast ChoK (IC50 = 17 μM); has antiproliferative activity against HT-29 colon cancer cells (IC50 = 2 μM)
Cayman Chemical BD 1008hydrobromIde 50mg
A selective antagonist of the σ1 receptor (Ki = 2 nM) that displays 4-fold selectivity for σ1 over σ2; used to modulate signaling through σ receptors by cocaine and in models of learning and memory impairment
Cayman Chemical ValrocemIde 50mg
An anticonvulsant; protects against MES-, PTZ-, picrotoxin-, or bicuculline-induced seizures in mice (ED50s = 151, 132, 275, and 248 mg/kg, respectively); prevents sound-induced seizures in Frings audiogenic-sensitive mice (ED50 = 52 mg/kg) and MES-induced seizures in rats (ED50 = 73 mg/kg); prevents seizures in corneally kindled rats (ED50 = 161 mg/kg)
Cayman Chemical 1OHexadecylsnglycerol 100mg
An alkyl glyceryl ether; reduces UVB-induced cell death and production of ROS and PGE2 in NHEKs; increases coronary flow and left ventricular developed pressure and reduces MDA formation ex vivo in a rat heart model of ischemia/reperfusion injury
Cayman Chemical NItrendIpIn 50mg
A dihydropyridine used as an antihypertensive agent due to its ability to block L-type and T-type calcium channels; also binds to adenosine A1, A2A, and A3 receptors with Ki values of 8.96, 23.0, and 8.3 µM, respectively
Cayman Chemical DIbutyrylCyclIc GMPsodIum 50mg
A cell-permeable, cGMP analog that activates cGMP-dependent protein kinase
Cayman Chemical SncyclInhydrochlorIde 100mg
A semisynthetic tetracycline antibiotic; more active than tetracycline against 339 strains of anaerobic bacteria (MIC90s = 1 and 32 μg/ml, respectively); active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains (MICs = 0.06-1 μg/ml); active against S. aureus in mice (ED50s = 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively)
Cayman Chemical CyclogunIlhydrochlorIde 50mg
The active metabolite of proguanil; formed from proguanil by CYP2C19 and CYP3A in human liver microsomes; an inhibitor of DHFR (Kis = 1.5 and 0.79 nM for the P. falciparum and P. berghei enzymes, respectively); active against ten P. falciparum field isolates (IC50s = 0.12-1,400 UG/ml); reduces parasitemia in a mouse model of P. berghei infection (ED50 = 2 mg/kg); reduces parasitemia in a rhesus monkey model of P. cynomolgi infection at 0.3 mg/kg
Cayman Chemical 2 5-nhydro-D-mnItol 50mg
An antimetabolic fructose analogue that increases food intake in rats
Cayman Chemical TrIGalNAc OAc3trIfluoroac 50mg
An intermediate in the synthesis of LYTACs with anticancer activity
Cayman Chemical ImatInIbmesylate 50mg
An inhibitor of the receptor tyrosine kinases c-Abl, Bcr-Abl, PDGFR, and c-Kit; inhibits ligand-stimulated autophosphorylation of PDGFR and c-Kit (IC50s = ~0.3 and ~0.1 μM, respectively); inhibits the proliferation of Bcr-Abl-dependent R10(–) cells (IC50s = ~35-40 nM) and HMC-1 cells expressing constitutively active c-Kit in a concentration-dependent manner; prolongs survival in a mouse model of chronic myeloid leukemia at 100 mg/kg twice daily; inhibits replication of MERS-CoV and SARS-CoV in Vero E6 cells at 25 and 50 µM; reduces viral titers in IBV-infected Vero cells at 10 µM
Cayman Chemical NorcholIc AcId 100mg
A bile acid and derivative of cholic acid; urine levels are increased in patients with liver cirrhosis or CTX