Human Sera
Cayman Chemical LIpId OA2hydrochlorIde 50mg
An ionizable cationic lipid; has been used in the generation of single-component LNPs for the delivery of siRNA; LNPs containing lipid OA2 and siRNA targeting Socs1 decrease Socs1 expression by ~50% in isolated mouse BMDCs; vaccination with ovalbumin-induced isolated mouse BMDCs transfected with LNPs composed of lipid OA2 and Socs1-targeting siRNA increases survival and decreases tumor volume in a B16-OVA murine melanoma model
Cayman Chemical SMethylLCysteInSoxIde 100mg
An analog of alliin found in some cruciferous vegetables that can be converted through alliinase activity into a volatile thiosulfinate
Cayman Chemical A2764hydrochlorIde 50mg
An inhibitor of K2P18.1/TRESK (IC50 = 11.8 µM in ionomycin-stimulated Xenopus oocytes expressing the mouse receptor); selective for K2P18.1/TRESK over K2P2.1/TREK1, K2P10.1/TREK2, K2P4.1/TRAAK, K2P3.1/TASK1, K2P3.2/TASK2, K2P3.3/TASK3, K2P16.1/TALK1, and K2P13.1/THIK1 at 100 µM; inhibits basal potassium currents in isolated mouse dorsal root ganglion neurons at 100 µM
Cayman Chemical GlucosylceramIdebovIn but 50mg
A mixture of glucosylceramides isolated from soy; levels decrease during cold acclimatization in plants; involved in the regulation of virulence in fungi and act as elicitors in plants, stimulating plant defense mechanisms; increased levels are associated with obesity-induced insulin resistance in mice and with neuronal deficits observed in neuronopathic Gaucher disease
Quidel Corporation Normal human serum depleted of complement C1q protein.
Normal human serum depleted of complement C1q protein.
Cayman Chemical VInorelbIntartrate 50mg
An inhibitor of microtubule polymerization that blocks mitosis at the metaphase/anaphase transition, preventing HeLa cell proliferation (IC50 = 1.25 nM)
Cayman Chemical 1AmIno1deoxyDfructoseh 50mg
An amino monosaccharide; induces site-specific DNA damage at pyrimidine residues in cell-free assays; 1-amino-1-deoxy-D-fructose moieties have been found as a component of fructosamines
Cayman Chemical R S-3 5-DHPG 50mg
An agonist of group I mGluRs; induces phosphoinositol hydrolysis in MCB3901 cells expressing human mGluR1a and mGluR5a; potentiates NMDA-induced depolarizations in rat hippocampal slices at 10 µM; intrathecal administration increases mean blood pressure in anesthetized rats at 300 nmol/animal; induces seizures in rats at 1.5 µmol/animal, i.c.v.
Cayman Chemical Scopolamn 50mg
An alkaloid with diverse biological activities; an antagonist of mAChRs (Kis = 0.19, 1.41, and 0.18 nM for the rat M1, M2, and M3 receptors, respectively); reduces acetylcholine-induced contractions in isolated guinea pig ileum (IC50 = 8.1 nM); inhibits oxotremorine-induced tremors in mice (ED50 = 0.23 mg/kg); increases fine motor activity counts and ambulatory activity in rats in a home-cage activity test (ED50 = 0.12 mg/kg for both); has been used to induce learning deficiencies or amnesia in animal models
Cayman Chemical MetaproterenolhemIsulfate 50mg
A long-acting β2-AR agonist with bronchodilator actions; inhibits TGF-α-induced hepatocyte DNA syntheses and proliferation in vitro (IC50 = 15 nM); dose-dependently relaxes lung strips and increases heart rate and inotropy of right atria and left atria, respectively, isolated from guinea pig (pD2s = 6.4, 7.08, and 6.61, respectively)